Ro 6-3129: Difference between revisions

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    '''Ro 6-3129''', also known as '''16α-ethylthio-6-dehydroretroprogesterone''' or as '''16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione''', as well as '''16α-ethylthiodydrogesterone''', is a [[progestogen]] of the [[retroprogesterone]] group which was developed by [[Hoffmann-La Roche|Roche]] but was never marketed.<ref name="JUCKER2013">{{cite book | vauthors = Harper MJ | chapter = Contraception — retrospect and prospect | title = Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques | veditors = Jucker E | volume = 21 | issue = | pages = 293–407 (321) | date = 1977 | pmid = 339271 | doi = 10.1007/978-3-0348-7098-6_4 | isbn=978-3-0348-7098-6 |chapter-url=https://books.google.com/books?id=VFb2BwAAQBAJ&pg=PA321 }}</ref><ref name="pmid5458777">{{cite journal | vauthors = Larsson-Cohn U, Johansson ED, Wide L, Gemzell C | title = Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens | journal = The Journal of Obstetrics and Gynaecology of the British Commonwealth | volume = 77 | issue = 9 | pages = 840–846 | date = September 1970 | pmid = 5458777 | doi = 10.1111/j.1471-0528.1970.tb04411.x | s2cid = 6176278 }}</ref><ref name="DixonHudson1973">{{cite journal| vauthors = Dixon R, Hudson S, Darragh A |title=Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep|journal=Contraception|volume=8|issue=1|year=1973|pages=53–65|issn=0010-7824|doi=10.1016/0010-7824(73)90159-5}}</ref> It shows greater [[potency (pharmacology)|potency]] than [[dydrogesterone]] in [[bioassay]]s.<ref name="RoyalCollege1970">{{cite book|title=The Journal of Obstetrics and Gynaecology of the British Commonwealth|url=https://books.google.com/books?id=_gtA33qrWkIC|year=1970|publisher=Royal College of Obstetricians and Gynaecologists}}</ref>
    '''Ro 6-3129''', also known as '''16α-ethylthio-6-dehydroretroprogesterone''' or as '''16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione''', as well as '''16α-ethylthiodydrogesterone''', is a [[progestogen]] of the [[retroprogesterone]] group which was developed by [[Hoffmann-La Roche|Roche]] but was never marketed.<ref name="JUCKER2013">{{cite book | vauthors = Harper MJ | title = Progress in Drug Research | chapter = Contraception — retrospect and prospect | series = <!-- Progress in Drug Research--> |journal= <!-- Citation bot -->| veditors = Jucker E | volume = 21 | issue = | pages = 293–407 [321] | date = 1977 | pmid = 339271 | doi = 10.1007/978-3-0348-7098-6_4 | isbn=978-3-0348-7098-6 |chapter-url=https://books.google.com/books?id=VFb2BwAAQBAJ&pg=PA321 }}</ref><ref name="pmid5458777">{{cite journal | vauthors = Larsson-Cohn U, Johansson ED, Wide L, Gemzell C | title = Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens | journal = The Journal of Obstetrics and Gynaecology of the British Commonwealth | volume = 77 | issue = 9 | pages = 840–846 | date = September 1970 | pmid = 5458777 | doi = 10.1111/j.1471-0528.1970.tb04411.x | s2cid = 6176278 }}</ref><ref name="DixonHudson1973">{{cite journal| vauthors = Dixon R, Hudson S, Darragh A |title=Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep|journal=Contraception|volume=8|issue=1|year=1973|pages=53–65|issn=0010-7824|doi=10.1016/0010-7824(73)90159-5}}</ref> It shows greater [[potency (pharmacology)|potency]] than [[dydrogesterone]] in [[bioassay]]s.<ref name="RoyalCollege1970">{{cite book|title=The Journal of Obstetrics and Gynaecology of the British Commonwealth|url=https://books.google.com/books?id=_gtA33qrWkIC|year=1970|publisher=Royal College of Obstetricians and Gynaecologists}}</ref>


    == References ==
    == References ==

    Latest revision as of 06:48, 3 April 2024

    Ro 6-3129
    Clinical data
    Other names16α-Ethylthiodydrogesterone; 16α-Ethylthio-6-dehydroretroprogesterone; 16α-Ethylthio-9β,10α-pregna-4,6-diene-3,20-dione
    Routes of
    administration    		Oral
    Identifiers
    • (1R,2S,10S,11S,13R,14S,15S)-14-Acetyl-13-(ethylsulfanyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-6,8-dien-5-one
    CAS Number
    ChemSpider
    Chemical and physical data
    FormulaC23H32O2S
    Molar mass372.57 g·mol−1
    3D model (JSmol)
    • CCS[C@@H]1C[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]2(C)[C@H]1C(C)=O
    • InChI=1S/C23H32O2S/c1-5-26-20-13-19-17-7-6-15-12-16(25)8-10-22(15,3)18(17)9-11-23(19,4)21(20)14(2)24/h6-7,12,17-21H,5,8-11,13H2,1-4H3/t17-,18-,19+,20-,21+,22-,23?/m1/s1
    • Key:OWNPEOXTHUGQDI-LWAHLCLDSA-N

    Ro 6-3129, also known as 16α-ethylthio-6-dehydroretroprogesterone or as 16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione, as well as 16α-ethylthiodydrogesterone, is a progestogen of the retroprogesterone group which was developed by Roche but was never marketed.[1][2][3] It shows greater potency than dydrogesterone in bioassays.[4]

    References[edit]

    1. ^ Harper MJ (1977). "Contraception — retrospect and prospect". In Jucker E (ed.). Progress in Drug Research. Vol. 21. pp. 293–407 [321]. doi:10.1007/978-3-0348-7098-6_4. ISBN 978-3-0348-7098-6. PMID 339271.
    2. ^ Larsson-Cohn U, Johansson ED, Wide L, Gemzell C (September 1970). "Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens". The Journal of Obstetrics and Gynaecology of the British Commonwealth. 77 (9): 840–846. doi:10.1111/j.1471-0528.1970.tb04411.x. PMID 5458777. S2CID 6176278.
    3. ^ Dixon R, Hudson S, Darragh A (1973). "Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep". Contraception. 8 (1): 53–65. doi:10.1016/0010-7824(73)90159-5. ISSN 0010-7824.
    4. ^ The Journal of Obstetrics and Gynaecology of the British Commonwealth. Royal College of Obstetricians and Gynaecologists. 1970.
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