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Enhanced homology searching through genome reading frame predetermination
Motivation: Many bioinformatic approaches exist for finding novel genes within genomic sequence data. Traditionally, homology search-based methods are often the first approach employed in determining whether a novel gene exists that is similar to a ...
Identification of circular codes in bacterial genomes and their use in a factorization method for retrieving the reading frames of genes
We developed a statistical method that allows each trinucleotide to be associated with a unique frame among the three possible ones in a (protein coding) gene. An extensive gene study in 175 complete bacterial genomes based on this statistical approach ...
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