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Assessing the Stability of the marketed mAb drug Dupixent® using wNMR
Quality control holds immense importance in pharmaceutical production to ensure therapeutic efficacy and the mitigation of adverse reactions. Formulations of high concentrations of therapeutic proteins are becoming more common, which poses several concerns including complications in formulation and drug administration. Many existing analytical methods aimed at detecting these complications involve...
IBBR at Maryland Day!
On Saturday, April 27th, IBBR visited College Park for Maryland Day! The rain did not deter the thousands of visitors for a fun-filled day of learning (and lots of giveaways). Our booth, located in the Jeong H. Kim Engineering Building in the Science and Tech Way “Learning Neighborhood” featured 3...
Urmil Dave receives American Society for Microbiology Fellowship
Urmil Dave in the Nelson Laboratory has been selected as a fellow in the American Society for Microbiology (ASM) Future Leaders Mentorship Fellowship (FMLF) program. This is a 2-year program that matches doctoral students from historically excluded communities in the microbial sciences with experts (mentors) across varied career sectors with...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Wednesday, May 8, 2024 - 11:00am
BMD Staff Seminar G. Wang/K. Kiesler, .04/.06
G. Wang/K. Kiesler, .04/.06
Tuesday, May 14, 2024 - 11:00am
Wednesday, May 15, 2024 - 11:00am
Recent Publications
An important consideration when expressing mAbs in Escherichia coli.
Monoclonal antibodies (mAbs) are a driving force in the biopharmaceutical industry. Therapeutic mAbs are usually produced in mammalian cells, but there has been a push towards the use of...
FFParam-v2.0: A Comprehensive Tool for CHARMM Additive and Drude Polarizable Force-Field Parameter Optimization and Validation.
Developing production quality CHARMM force-field (FF) parameters is a very detailed process involving a variety of calculations, many of which are specific for the molecule of interest. The first...
Extremophiles in a changing world.
Extremophiles and their products have been a major focus of research interest for over 40 years. Through this period, studies of these organisms have contributed hugely to many aspects of the...
Redox active plant phenolic, acetosyringone, for electrogenetic signaling.
Redox is a unique, programmable modality capable of bridging communication between biology and electronics. Previous studies have shown that the E. coli redox-responsive OxyRS regulon can be...
Identifying and Assessing Putative Allosteric Sites and Modulators for CXCR4 Predicted through Network Modeling and Site Identification by Ligand Competitive Saturation.
The chemokine receptor CXCR4 is a critical target for the treatment of several cancer types and HIV-1 infections. While orthosteric and allosteric modulators have been developed targeting its...